Generic Differin 15 gr. Buy Differin/Adapalene.

Differin: 15 gr
Active ingredient: Adapalene

Where can I order Differin without a prescription?
Differin is an acne medication that can be bought without a prescription. It contains a retinoid metabolite, adapalene, which has comedolytic and anti-inflammatory effects.

Indications for use

Differin is used to treat acne of varying severity. Depending on the clinical picture of the disease, it can be used both as monotherapy and as part of complex treatment.

Non-standard application of Differin

Differin has the ability to inhibit keratinocyte differentiation, which makes it recommended for the treatment of keratosis pilaris, calluses and plantar warts. In addition, Differin can be used to restore the foreskin in men after circumcision.

Proof of effectiveness of Differin

The effect of Differin was studied in vivo (in living organisms) and in vitro (in vitro). It has been proven that the active substance adapalene affects inflammatory factors. It suppresses the migration of leukocytes at the site of inflammation and the metabolism of arachidonic acid. The mechanism of action of Differin is also associated with interaction with specific gamma receptors of the epidermis, due to which the accumulation of epithelial cells in the hair follicle is reduced and the likelihood of the formation of comedones (blackheads) is reduced.
Effect of Differin on the body when taken systematically
Differin is slightly absorbed through the skin (approximately 4% of the applied dose), so it does not affect the functioning of the body. The drug is excreted along with bile.

Directions for use and doses

Differin is applied to the skin, to those places where there is acne. It is available in the form of a gel and cream, which allows the drug to be used by people with different skin types. Differin must be applied evenly. Do not rub it into the skin too much, so as not to injure the inflamed areas. It is best to apply Differin once a day, in a thin layer at night. The skin must be pre-cleaned and dry.

Therapeutic effect

Differin provides significant relief of symptoms of the disease after 1-2 months of systematic use. After another month, there is a lasting improvement in the condition of the skin. The decision on further use of the drug or a second course of treatment is made by the attending physician.


Excessive application of Differin to affected areas of the skin will not speed up treatment and is therefore not advisable. In addition, violation of the dosage regimen can lead to the development of such unpleasant symptoms as:

• hyperemia of the skin;
• peeling;
• feeling of discomfort.

Drug interactions

The active ingredient Differin is poorly absorbed through the skin, so there is no reason to believe that taking it will adversely affect the action of any medications.
No interactions with other external medications have been established. However, when using Differin in the evening, it is acceptable to use some acne medications in the morning, for example:

• weak solution of erythromycin (no more than 4%);
• clindamycin phosphate (1% based on base);
• water-based benzoyl peroxide gels (up to 10%).

Simultaneous use of retinoids or drugs with a mechanism of action similar to Differin is not advisable, in order to avoid an inflammatory process on the skin. It is also not recommended to use the following cosmetics and medicinal products:

• scrubs;
• peelings;
• products with astringent or irritating effects;
• alcohol-containing products.

special instructions

Differin should not be applied to the mucous membranes of the eyes and lips, but if this happens, you need to rinse the affected areas with plenty of warm water. If the inflammation is severe, you should consult a doctor. If even a small amount of Differin is accidentally ingested, the stomach should be rinsed and treated symptomatically.
When using Differin, it is not recommended to stay in the sun for long periods of time because it may cause irritation.
Differin is not effective as a single treatment in patients with severe acne over large areas of skin.

Contraindications to the use of Differin

In some situations, the use of Differin can lead to negative consequences. The drug is contraindicated in the following cases:

• the patient has hypersensitivity to the active substance – adapalene or any of the components of the gel or ointment;
• skin injuries (scratches, abrasions or wounds);
• sunburn of any degree;
• eczema;
• children under 12 years of age, since no studies have been conducted on this group of patients.

If a hypersensitivity reaction develops or excessive skin irritation occurs, you should stop using Differin and consult a specialist about the advisability of further treatment. In some situations, you may be able to reduce the frequency of Differin use until signs of inflammation subside and then resume therapy.

Use during pregnancy and lactation

Clinical studies of Differin in pregnancy are limited. Those patients who used Differin for a short period of time in early pregnancy did not experience any negative effects on the health of the fetus. But since there is no data on how the drug affects long-term use, Differin is not recommended for use during pregnancy.
Differin can be used during breastfeeding, since its absorption into the body is extremely low. However, you should not apply the drug to the chest so that Differin does not get on the baby’s oral mucosa.

The effect of Differin on concentration

Differin does not affect concentration, so you can drive a car or work with complex equipment when using it.

Buy Differin

Differin can be purchased at a pharmacy without a doctor’s prescription. But on our website you can order the drug online at a favorable price, because we offer a high-quality analogue – the generic Differin.

Advantages of generic Differin

Generic Differin has the same effect as the original drug, because it contains a similar active substance – adapalene. Adapalene has been tested in vitro, in animals, and in humans, to prove its effectiveness. All these studies affect the cost of the drug. After the patent of the original drug expired, a generic version of Differin was developed. And since there is no longer a need for research, the price of the drug has become more affordable.
Before purchasing generic Differin, you should consult a specialist.